This webinar highlights how U.S. Geological Survey scientists are advancing innovative, science based approaches to prevent, detect, and manage invasive species across diverse ecosystems. Presentations explore the role of invasion biology within a One Health framework, emerging point of use environmental DNA tools for invasive species, parasite, and pathogen surveillance, and the use of molecular techniques to understand wildlife and fish health. Speakers also examine applied research on contaminants and health effects in aquatic systems, strategies to reduce wildfire risk from invasive vegetation in Hawaii, and the development of acoustic deterrents to control invasive carp. Together, these talks demonstrate how USGS research supports ecosystem resilience, public health, and natural resource management nationwide.